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J Surg Oncol. 2005 Mar 15;89(4):256-63; discussion 263-4.

Pre-operative chemoradiotherapy with oral tegafur-uracil and leucovorin for rectal cancer.

Author information

1
Cancer Center, Taipei Veterans General Hospital & National Yang-Ming University, School of Medicine, Taipei, Taiwan, Republic of China.

Erratum in

  • J Surg Oncol. 2005 May 1;90(2):106.

Abstract

BACKGROUND:

To evaluate the efficacy and toxicity of pre-operative radiotherapy (RT) combined with oral tegafur-uracil (UFUR) plus leucovorin (LV) in rectal cancer.

PATIENTS:

Sixty-five patients with rectal adenocarcinoma (clinical staged T2-4N0-2M0) received pelvic RT of 45 Gy in 20 fractions over 28 days. Concurrent chemotherapy consisted of UFUR (200 mg/m(2)/day) and LV (45 mg/day) on day 1-28. UFUR (250 mg/m(2)/day) and LV were continued on day 36-63. Surgery was performed on day 70.

RESULTS:

Sixty-three patients completed the concurrent chemoradiotherapy (CCRT) and 56 received curative or palliative surgery. Among the 52 patients receiving curative resection, downstaging (DS) occurred in 39 (75%), pathological complete response in 13 (25%), and sphincter preservation was achieved in 16 of 29 (55%) with lower-seated tumors. With a median follow-up time of 33 months, local failure developed in 4 (8%) and distant metastases occurred in 7 (14%). The 3-year overall survival was 92% and disease-free survival 76%. For all 65 patients, grade 3-4 diarrhea developed in 6 (9%) and grade 3-4 leucopenia observed in 2 (3%).

CONCLUSIONS:

Oral UFUR + LV administered with pre-operative RT are effective in tumor DS, pathological complete response, and sphincter preservation with tolerable toxicity in rectal cancer.

PMID:
15726610
DOI:
10.1002/jso.20168
[Indexed for MEDLINE]

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