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Clin Exp Dermatol. 2005 Mar;30(2):134-6.

Pyoderma gangrenosum outside the context of inflammatory bowel disease treated successfully with infliximab.

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Department of Dermatology, Royal Free Hospital, London, UK.


A 63-year-old man with chronic lymphocytic leukaemia developed pyoderma gangrenosum following minor trauma to the leg. He required intensive inpatient management with a multitude of treatments including larval therapy, surgical debridement, ciclosporin, methotrexate, thalidomide, pulsed intravenous methylprednisolone and high-dose intravenous immunoglobulin, clofazamine and high dose oral corticosteroids, none of which were helpful. Treatment complications included steroid-induced diabetes, Cushing's syndrome and perforated peptic ulcer. The pyoderma remained refractory to treatment and continued to extend until he received intravenous infliximab 5 mg/kg at weeks 0, 2 and 6.

[Indexed for MEDLINE]

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