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Nat Neurosci. 2005 Mar;8(3):270-2. Epub 2005 Feb 20.

Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice.

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  • 1Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK.

Abstract

Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.

PMID:
15723058
DOI:
10.1038/nn1412
[PubMed - indexed for MEDLINE]
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