Format

Send to

Choose Destination
Environ Res. 2005 May;98(1):120-6.

Reproductive outcomes in DDT applicators.

Author information

1
Occupational Health Section, Department of Public Health, University of Cagliari, Via San Giorgio 12, Cagliari 09124, Italy. coccop@pacs.unica.it

Abstract

OBJECTIVES:

To explore reproductive outcomes in relation to occupational exposure to DDT.

METHODS:

We inquired into the reproductive history, including total number of children, sex distribution in the offspring, time-to-pregnancy, and number of spontaneous abortions and stillbirths, of the spouses of 105 men first exposed to DDT in a 1946-1950 anti-malarial campaign in Sardinia, Italy. The time-to-pregnancy in months at the first successful conception was estimated from population Registrars. Cumulative DDT exposure during the anti-malarial campaign was retrospectively estimated.

RESULTS:

The stillbirth rate was elevated and the male/female ratio in the offspring was reversed among DDT-exposed workers, and particularly among DDT applicators, compared to the unexposed subjects. Among DDT applicators, the stillbirth rate increased and the male/female ratio decreased by the tertile of cumulative DDT exposure. The fecundity ratio among spouses of DDT applicators was 0.72 (95% CI, 0.41,1.21) compared to the unexposed. The average number of children and abortion rate were unaffected by DDT exposure.

CONCLUSIONS:

The low statistical power of our study does not allow definitive conclusions. However, the results prompt further in-depth research into adverse reproductive outcomes and reduced fertility among men heavily exposed to DDT.

PMID:
15721892
DOI:
10.1016/j.envres.2004.09.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center