Send to

Choose Destination
See comment in PubMed Commons below
Psychophysiology. 2005 Jan;42(1):25-32.

Memory-based or afferent processes in mismatch negativity (MMN): a review of the evidence.

Author information

Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, Helsinki, Finland.


The mismatch negativity (MMN) is an electromagnetic response to any discriminable change in regular auditory input. This response is usually interpreted as being generated by an automatic cortical change-detection process in which a difference is found between the current input and the representation of the regular aspects of the preceding auditory input. Recently, this interpretation was questioned by Jääskeläinen et al. (2004) who proposed that the MMN is a product of an N1 (N1a) difference wave emerging in the subtraction procedure used to visualize and quantify the MMN. We now evaluate this "adaptation hypothesis" of the MMN in the light of the available data. It is shown that the MMN cannot be accounted for by differential activation of the afferent N1 transient detectors by repetitive ("standard") stimuli and deviant ("novel") stimuli and that the presence of a memory representation of the standard is required for the elicitation of MMN.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center