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Chem Commun (Camb). 2005 Feb 28;(8):1016-8. Epub 2005 Jan 4.

Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton.

Author information

  • 1Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi, Niigata, 950-2181, Japan.

Abstract

The cloning and functional expression of Mycobacterium tuberculosis Rv3377c in Escherichia coli revealed that this gene encodes the diterpene cyclase for producing (+)-5(6),13-halimadiene-15-ol, which accepts geranylgeranyldiphosphate as the intrinsic substrate.

PMID:
15719101
DOI:
10.1039/b415346d
[PubMed - indexed for MEDLINE]
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