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Physiol Res. 2005;54(6):639-44.

Biological half-life of bromide in the rat depends primarily on the magnitude of sodium intake.

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1
Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Pragu 4, Czech Republic. pavelka@biomed.cas.cz

Abstract

The parallel course of the excretion rates of bromide and sodium ions was demonstrated in adult male and female rats administered simultaneously with potassium 82Br-bromide and 24Na-sodium chloride. The animals were exposed to various intakes of sodium ions accompanied with five different anions: Br-, Cl-, HCO3-, ClO4-, and SCN-. Regardless of the anion accompanying the sodium ion, the excretion rates of 82Br- and 24Na+ ions were proportional to the magnitude of sodium intake in the animals. Hence, we have proved our hypothesis that the biological half-life of bromide depends on the magnitude of sodium intake rather than on the intake of chloride.

PMID:
15717853
[Indexed for MEDLINE]
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