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J Infect Dis. 2005 Mar 15;191(6):1000-4. Epub 2005 Jan 31.

Cross-serotype neutralization of dengue virus in Aotus nancymae monkeys.

Author information

1
US Naval Medical Research Center Detachment, Lima, Peru. kochelt@nmrc.navy.mil

Abstract

Previously, we observed that serum from humans immune to dengue serotype 1 (dengue-1) neutralized the American genotype of dengue serotype 2 (American-2) to a greater extent than it neutralized the Asian genotype of dengue serotype 2 (Asian-2). To determine if this activity is protective, Aotus nancymae monkeys were infected with dengue-1 followed by either American-2 or Asian-2. Dengue-1-infected animals produced antibody with neutralizing titers of 2656 antibodies against dengue-1, 409 against American-2, and <20 against Asian-2. Infection with American-2 did not produce detectable viremia in either dengue-1-immune or dengue-1-naive animals. These findings support the hypothesis that dengue-1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue-1 and American-2.

PMID:
15717278
DOI:
10.1086/427511
[Indexed for MEDLINE]

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