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Australas Psychiatry. 2004 Mar;12(1):74-6.

Combined use of amisulpride and clozapine for patients with treatment-resistant schizophrenia.

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1
Bundaberg Integrated Mental Health Service, Bundaberg, Queensland 4670, Australia.

Abstract

OBJECTIVE:

To report on a trial of adding amisulpride to clozapine.

METHODS:

Description of six cases.

RESULTS:

Six patients who had been on clozapine were commenced on amisulpride. All patients had had unwanted effects with clozapine, particularly sedation, hypersalivation, or weight gain. Five patients reported a high level of satisfaction with the regimen, having a reduction in the level of sedation and improvement in levels of motivation and energy, without recurrence of positive symptoms.

CONCLUSION:

The combined use of amisulpride and clozapine would appear to be an appropriate and beneficial treatment.

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