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J Med Chem. 2005 Feb 24;48(4):1256-9.

Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus.

Author information

1
Institute of Medical Virology, Johann Wolfgang Goethe University Frankfurt, Paul-Ehrlich-Strasse 40, 60596 Frankfurt, Germany.

Abstract

Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.

PMID:
15715493
DOI:
10.1021/jm0493008
[Indexed for MEDLINE]

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