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Nat Rev Mol Cell Biol. 2005 Mar;6(3):268-75. doi: 10.1038/nrm2239.

Do inducers of apoptosis trigger caspase-independent cell death?

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Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA.


Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantling and clearance of the dying cell. However, mounting evidence indicates that a cell that has been treated with an apoptotic inducer can also initiate a suicide programme that does not rely on caspase activation. Here, we present recent findings and discuss the physiological relevance of caspase-independent cell death.

[Indexed for MEDLINE]

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