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Nat Rev Mol Cell Biol. 2005 Mar;6(3):268-75. doi: 10.1038/nrm2239.

Do inducers of apoptosis trigger caspase-independent cell death?

Author information

1
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92121, USA. jerrychipuk@hotmail.com

Abstract

Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantling and clearance of the dying cell. However, mounting evidence indicates that a cell that has been treated with an apoptotic inducer can also initiate a suicide programme that does not rely on caspase activation. Here, we present recent findings and discuss the physiological relevance of caspase-independent cell death.

PMID:
15714200
DOI:
10.1038/nrm1573
[Indexed for MEDLINE]

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