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Bioorg Med Chem Lett. 2005 Mar 1;15(5):1505-7.

Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo.

Author information

1
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China. chyang@mail.shcnc.ac.cn

Abstract

The synthesis of benzothiophenes containing a piperazine side chain and their binding affinities for estrogen receptors are described. These compounds bearing piperazine side chains were identified to be high-affinity ligands with high selectivity for ER alpha subtype. They were also potent agonists in bone tissue.

PMID:
15713417
DOI:
10.1016/j.bmcl.2004.12.074
[Indexed for MEDLINE]

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