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Bioorg Med Chem Lett. 2005 Mar 1;15(5):1375-8.

The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.

Author information

1
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. pauline.ting@spcorp.com

Abstract

Bipiperidine amide 1 has been identified as a CC chemokine receptor 3 (CCR3) antagonist. Optimization of its structure-activity relationship has resulted in the identification of cis (R,R)-4-[(3,4-dichlorophenyl)methyl]-3-hydroxymethyl-1'(6-quinolinylcarbonyl)-1,4'-bipiperidine 14n, which exhibits potent receptor affinity and inhibition of both calcium flux and eosinophil chemotaxis.

PMID:
15713390
DOI:
10.1016/j.bmcl.2005.01.016
[Indexed for MEDLINE]

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