Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Pharmacol. 2005 Mar 1;69(5):733-40. Epub 2005 Jan 21.

Inhibition of tristetraprolin expression by dexamethasone in activated macrophages.

Author information

1
The Immunopharmacological Research Group, University of Tampere, Medical School, FIN-33014 University of Tampere, Finland.

Abstract

Tristetraprolin (TTP) is a factor that regulates mRNA stability and the expression of certain inflammatory genes. In the present study, we found that TTP expression was increased in macrophages exposed to bacterial lipopolysaccharide (LPS). Dexamethasone and dissociated steroid RU24858 inhibited LPS-induced TTP protein and mRNA expression and the inhibitory effect was reversed by a glucocorticoid receptor antagonist mifepristone. Histone deacetylase inhibitors trichostatin A (TSA) and apicidin reduced the inhibitory effect of dexamethasone and RU24858 on TTP expression, but the glucocorticoids did not alter TTP mRNA half-life. These results suggest that anti-inflammatory steroids reduce TTP expression in activated macrophages by a glucocorticoid response element (GRE)-independent mechanism, possibly through histone deacetylation and transcriptional silencing.

PMID:
15710351
DOI:
10.1016/j.bcp.2004.11.027
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center