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J Virol. 2005 Mar;79(5):3169-73.

Equine herpesvirus 1 utilizes a novel herpesvirus entry receptor.

Author information

1
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1246 Biomedical Science Tower, Pittsburgh, PA 15261, USA.

Abstract

The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.

PMID:
15709036
PMCID:
PMC548480
DOI:
10.1128/JVI.79.5.3169-3173.2005
[Indexed for MEDLINE]
Free PMC Article
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