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Ann Rheum Dis. 2005 Mar;64 Suppl 2:ii30-6.

Psoriasis pathophysiology: current concepts of pathogenesis.

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1
Laboratory for Investigative Dermatology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA. jgk@rockefeller.edu

Abstract

Psoriasis vulgaris is a common skin disorder characterised by focal formation of inflamed, raised plaques that constantly shed scales derived from excessive growth of skin epithelial cells. The disease is defined by a series of linked cellular changes in the skin: hyperplasia of epidermal keratinocytes, vascular hyperplasia and ectasia, and infiltration of T lymphocytes, neutrophils, and other types of leucocyte in affected skin. In a relatively short period, psoriasis vulgaris has been conceptualised as a T lymphocyte mediated autoimmune disease and new biological therapies that target T cells have just entered routine clinical practice. Similarly, rapid progress has been made towards dissecting cellular and molecular pathways of inflammation that contribute to disease pathogenesis. This short review presents current pathogenic concepts that have emerged from genetic, genomic, and cellular information obtained in basic studies and from clinical studies of selective immune targeting drugs.

PMID:
15708932
PMCID:
PMC1766865
DOI:
10.1136/ard.2004.031120
[Indexed for MEDLINE]
Free PMC Article
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