Format

Send to

Choose Destination
See comment in PubMed Commons below
Dev Biol. 2005 Mar 1;279(1):244-51.

Cyclin D involvement demarcates a late transition in C. elegans embryogenesis.

Author information

1
Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21218, USA. jly@alum.mit.edu

Abstract

During development, progression through the cell cycle must be coordinately regulated with cellular differentiation. Despite significant progress in identifying genes required independently for each of these processes, the molecules which facilitate this cross talk have for the most part been elusive. Using the six macrophage-like coelomocytes of the nematode Caenorhabditis elegans as a model system to gain insight into the mesodermal differentiation pathway, we have isolated a set of mutants that alter coelomocyte numbers. One of these mutations, cc600, apparently results from a partial loss-of-function in the C. elegans cyclin D gene, cyd-1. The mutant has coelomocyte-specific defects without changes in other lineages. The mutants show that cell growth, terminal differentiation and cellular function proceed in the absence of cyd-1 activity and cell division. The results suggest that certain mesodermal lineages may be uniquely affected by changes in cyd-1 activity.

PMID:
15708572
DOI:
10.1016/j.ydbio.2004.12.022
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center