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Drug Discov Today. 2005 Feb 1;10(3):205-12.

Functional genomics using high-throughput RNA interference.

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  • 1Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Fabeckstrasse 60-62, 14195 Berlin, Germany.


RNA interference (RNAi) describes the post-transcriptional silencing of gene expression that occurs in response to the introduction of double-stranded RNA into cells. Application of RNAi in experimental systems has provided a great leap forward in the elucidation of gene function. To facilitate large-scale functional genomics studies using RNAi, several high throughput approaches have been developed based on microarray or microwell assays. Recent establishment of large libraries of RNAi reagents combined with a variety of detection assays further opens the door for genome-wide screens of gene function in mammalian cells.

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