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World J Surg. 2005 Mar;29(3):258-63.

Role of proteases in pancreatic carcinoma.

Author information

1
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 6550 Fannin Street, Houston, Texas 77030, USA.

Abstract

Proteases play an important role in cancer invasion and metastasis. In this review we specifically discuss the role of these proteases in pancreatic carcinoma. Serine proteases and matrix metalloproteinases are the focus of intense research, as they appear to be related to the process of tumor progression. We discuss the diagnostic and prognostic value of these two groups of proteases. Lastly, we report on the current and recent clinical trials focusing on inhibition of these proteases.

PMID:
15706437
DOI:
10.1007/s00268-004-7816-3
[Indexed for MEDLINE]

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