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J Physiol. 2005 May 15;565(Pt 1):9-17. Epub 2005 Feb 10.

Early origins of obesity: programming the appetite regulatory system.

Author information

1
Discipline of Physiology, Centre for the Early Origins of Adult Health, School of Molecular and Biomedical Sciences, University of Adelaide, SA 5005, Australia. caroline.mcmillen@adelaide.edu.au

Abstract

There is evidence that changes in perinatal nutrition programme the development of relative fat mass and the regulation of appetite in adult life. These studies have been primarily in the rodent utilizing maternal overnutrition or undernutrition imposed at different stages of pregnancy and beyond, mapping of neuropeptide localization and activity and appropriate null mutant models. Whilst the rodent offers significant advantages in terms of a short gestation and the availability of useful transgenic and null mutant models, there are also advantages to using an animal model more akin to the human, in which all components of the 'fat-brain axis' are present before birth, such as the sheep. This review summarizes recent work on the expression and localization of the 'appetite regulatory' peptides in the fetal rodent and sheep hypothalamus and their potential role in the early programming of postnatal appetite and obesity.

PMID:
15705647
PMCID:
PMC1464497
DOI:
10.1113/jphysiol.2004.081992
[Indexed for MEDLINE]
Free PMC Article

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