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Emerg Infect Dis. 2005 Jan;11(1):103-5.

Human parechovirus 3 and neonatal infections.

Author information

1
Centre Hospitalier Universitaire de Québec and Laval University, Québec City, Québec, Canada. Guy.Boivin@crchul.ulaval.ca

Abstract

A third serotype of human parechovirus (HPeV) has been recently isolated from stool specimens of a young Japanese child with transient paralysis. We report 3 additional cases of neonatal sepsis caused by HPeV-3 in the fall of 2001 in Canadian infants 7-27 days old. All children were hospitalized with high fever, erythematous rash, and tachypnea for a median of 5 days. The viruses isolated from nasopharyngeal aspirates grew slowly on tertiary monkey kidney cells and were successfully passaged on Vero cells. The predicted amino acid identity of the VP0-VP3-VP1 region of the three viruses was 74.6%-74.8%, 73.4%-73.6%, and 97.0%-97.1% when compared to HPeV-1, -2, and -3 prototype strains, respectively. Although different, our isolates were closely related; amino acid identity was 99.6%-100% for the last 3 proteins.

PMID:
15705330
PMCID:
PMC3294360
DOI:
10.3201/eid1101.040606
[Indexed for MEDLINE]
Free PMC Article

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