Format

Send to

Choose Destination
J Org Chem. 2005 Feb 18;70(4):1467-70.

tert-Buyldiphenylsilylethyl ("TBDPSE"): a practical protecting group for phenols.

Author information

1
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.

Abstract

[reaction: see text] A new protection group for phenols, the 2-(tert-butyldiphenylsilyl)ethyl (TBDPSE) group, has been prepared and investigated. Protection of a variety of substituted phenols proceeds in good to excellent yield. The group is stable to mild acid, base, hydrogenolysis conditions, and lithium/halogen exchange on the protected phenol. Removal is achieved with strong acid or standard fluoride treatment.

PMID:
15704987
DOI:
10.1021/jo048192u
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center