Application of Mosher's method for absolute configuration assignment and resolution of 2-hydroxypyrrolizidinones

Chirality. 2005 Mar;17(3):149-53. doi: 10.1002/chir.20139.

Abstract

Derivatization of racemic 2-hydroxypyrrolizidinones with S-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride (MTPA-Cl) was successfully used for enantiomer separation and absolute configuration assignment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography
  • Crystallography, X-Ray
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Phenylacetates / chemistry*
  • Pyrrolidinones / chemistry*
  • Stereoisomerism

Substances

  • Phenylacetates
  • Pyrrolidinones
  • alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride