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Hum Gene Ther. 2005 Jan;16(1):1-16.

Helper-dependent adenoviral vectors for gene therapy.

Author information

1
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Helper-dependent adenoviral vectors possess a number of characteristics that make them attractive gene therapy vectors. These vectors are completely devoid of viral coding sequences and are able to mediate high-efficiency transduction in vivo to direct sustain high-level transgene expression with negligible chronic toxicity. This review focuses on advances in helper-dependent adenoviral vector technology, selected examples of in vivo studies of particular interest, and the issue of vector-mediated acute toxicity.

PMID:
15703484
DOI:
10.1089/hum.2005.16.1
[Indexed for MEDLINE]

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