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Nat Struct Mol Biol. 2005 Feb;12(2):110-2.

Reading signals on the nucleosome with a new nomenclature for modified histones.

Author information

1
Chromatin and Gene Expression Group, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK. b.m.turner@bham.ac.uk

Abstract

The tails of the four core histones are exposed on the nucleosome surface, where they are subject to a variety of enzyme-catalyzed, post-translational modifications. Modifications, singly or in combination, provide a source of information that can be used for signal transduction during ongoing processes, such as transcription, or as heritable epigenetic marks. A nomenclature is presented that allows patterns of histone modification to be clearly and unambiguously specified and that should facilitate discussion of their functional roles.

PMID:
15702071
DOI:
10.1038/nsmb0205-110
[Indexed for MEDLINE]

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