Format

Send to

Choose Destination
Bioinformatics. 2005 May 15;21(10):2558-9. Epub 2005 Feb 8.

Protein function prediction using the Protein Link EXplorer (PLEX).

Author information

1
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, 1 University Station, A4800, Austin, TX 78712-1064, USA.

Abstract

We introduce the Protein Link EXplorer (PLEX), a web-based environment that allows the construction of a phylogenetic profile for any given amino acid sequence, and its comparison with profiles of approximately 350,000 predicted genes from 89 genomes, as a means of interactively identifying functionally linked genes and predicting protein function. PLEX can be searched iteratively and also enables searches for chromosomal gene neighbors and Rosetta Stone linkages. PLEX search results are accompanied by quantitative estimates of linkage confidence, enabling users to take advantage of coinheritance, operon and gene fusion-based methods for inferring gene function and reconstructing cellular systems and pathways.

AVAILABILITY:

http://bioinformatics.icmb.utexas.edu/plex

PMID:
15701682
DOI:
10.1093/bioinformatics/bti313
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center