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Curr Opin Chem Biol. 2005 Feb;9(1):14-9.

Protein microarrays as tools for functional proteomics.

Author information

1
Harvard Institute of Proteomics, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 320 Charles Street, Cambridge, Massachusetts 02141, USA. joshua_labaer@hms.harvard.edu

Abstract

Protein microarrays present an innovative and versatile approach to study protein abundance and function at an unprecedented scale. Given the chemical and structural complexity of the proteome, the development of protein microarrays has been challenging. Despite these challenges there has been a marked increase in the use of protein microarrays to map interactions of proteins with various other molecules, and to identify potential disease biomarkers, especially in the area of cancer biology. In this review, we discuss some of the promising advances made in the development and use of protein microarrays.

PMID:
15701447
DOI:
10.1016/j.cbpa.2004.12.006
[Indexed for MEDLINE]

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