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Yao Xue Xue Bao. 2004 Oct;39(10):831-5.

[Detection of hepatotoxic pyrrolizidine alkaloids in Ligularia Cass. with LC/MSn].

[Article in Chinese]

Author information

  • 1College of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210038, China.

Abstract

AIM:

To detect the hepatotoxic pyrrolizidine alkaloids (HPA) in the genus Ligularia Cass..

METHODS:

The alkaloid extracts of Ligularia plant materials were detected and analyzed by the method of combination of TLC, and LC/MSn.

RESULTS:

Among 22 species of Ligularia Cass., HPA were detected in 18 species with LC/MSn, and no HPA was detected in the remaining 4 species.

CONCLUSION:

HPA was first detected with LC/MSn in L. tongelensis and other 15 species of Ligularia Cass.; HPA from these plants should be isolated, separated and identified and it is necessary to study the activities and toxicities of the HPA. The types and kinds of HPA from different species and sources are different, they should be detected separately.

PMID:
15700826
[PubMed - indexed for MEDLINE]
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