Echinosulfonic acid D: an ESI MSn evaluation of a new cytotoxic alkaloid from the New-Caledonian sponge Psammoclemma sp

Shai Rubnov; Camille Chevallier; Odile Thoison; Cécile Debitus; Olivier Laprevote; Daniel Guénard; Thierry Sévenet

doi:10.1080/1478641042000199851

Echinosulfonic acid D: an ESI MSn evaluation of a new cytotoxic alkaloid from the New-Caledonian sponge Psammoclemma sp

Nat Prod Res. 2005 Jan;19(1):75-9. doi: 10.1080/1478641042000199851.

Authors

Shai Rubnov¹, Camille Chevallier, Odile Thoison, Cécile Debitus, Olivier Laprevote, Daniel Guénard, Thierry Sévenet

Affiliation

¹ Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.

PMID: 15700649
DOI: 10.1080/1478641042000199851

Abstract

A new bromoindolesulfonic acid derivative, echinosulfonic acid D (1) was isolated from the New-Caledonian sponge Psammoclemma sp. in a minute quantity. The structure of the alkaloid was established by spectroscopic methods and, in particular, by ESI MSn experiments. Echinosulfonic acid D was cytotoxic to KB cells (IC50 2 microg/mL).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / pharmacology
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / pharmacology*
Inhibitory Concentration 50
KB Cells / drug effects
Phytotherapy*
Porifera*
Sulfonic Acids / chemistry
Sulfonic Acids / pharmacology*

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Indole Alkaloids
Sulfonic Acids
echinosulfonic acid D