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Paediatr Respir Rev. 2005 Mar;6(1):68-74.

Asthma genetics: pitfalls and triumphs.

Author information

1
Academic Department of Paediatrics, University Hospital of North Staffordshire, Newcastle, Stoke-on-Trent ST4 6QG, UK. lisaorwill@aol.com

Abstract

Asthma is a complex genetic disorder. Significant progress has been made in identifying genes that convey risk of development and expression of the asthma phenotype. This review critically examines the approaches that have been used, the successes achieved and the difficulties that have been encountered. The multi-factorial nature of the disease and the complex interplay of the various risk factors with one another have highlighted the importance of adequate power and study design in pinpointing genes of real interest.

PMID:
15698819
DOI:
10.1016/j.prrv.2004.11.007
[Indexed for MEDLINE]

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