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Bioorg Med Chem. 2005 Mar 1;13(5):1799-803.

A new route to trihydroxamate-containing artificial siderophores and synthesis of a new fluorescent probe.

Author information

1
Chimie, Ingénierie Moléculaire et Matériaux d'Angers, UMR 6200 du CNRS, 2 Boulevard Lavoisier, 49045 Angers Cedex, France.

Abstract

A fluorescent labelled artificial siderophore 1 was synthesized by coupling a 7-nitrobenz-2-oxa-1,3-diazole (NBD) derivative to the terminal amino group of a new trihydroxamate-containing amine 2, a ferrichrome-type siderophore that was obtained from tris(hydroxymethyl)aminomethane. Compound 1 was shown to be a suitable tool for experiments on siderophore transport and uptake processes in various organisms cells and particularly in Candida albicans cells.

PMID:
15698797
DOI:
10.1016/j.bmc.2004.11.053
[Indexed for MEDLINE]

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