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Eur J Surg Oncol. 2005 Mar;31(2):183-90.

Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients.

Author information

1
Department of Diagnostic Imaging, National Institute of Oncology, Budapest, Hungary.

Abstract

AIM:

To report the role of liver angiography in the staging of medullary thyroid cancer (MTC) patients.

MATERIAL AND METHODS:

Sixty MTC patients with persistent or recurrent hypercalcitonemia (n=49), a characteristic general symptom (diarrhea, n=4) or a normal basal calcitonin level without general symptoms (n=7) were investigated by dynamic liver CT, MRI and angiography between 06/1998 and 06/2002.

RESULTS:

Dual-phase CT and MRI investigations identified hepatic metastases with relatively low frequency (8/58 on MRI, and 7/60 on CT). Angiography indicated liver involvement in 54/60 cases. The hepatic metastases were typically multiple, hypervascular, small foci (only 13 foci measured >/=10 mm). With one exception significant disease progression was not observed over 5 years of follow-up.

CONCLUSIONS:

Liver angiography is a powerful tool to reveal hepatic metastases in MTC patients. Frequent, inoperable liver metastases in hypercalcitoninemic MTC patients demonstrate that secondary lymph node dissection is an inefficient technique for restoration of a normal calcitonin level.

PMID:
15698736
DOI:
10.1016/j.ejso.2004.06.011
[Indexed for MEDLINE]

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