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Diagn Microbiol Infect Dis. 2005 Feb;51(2):135-7.

Pyrosequencing-based approach for rapid detection of rifampin-resistant Mycobacterium tuberculosis.

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Institute of Genetic Diagnosis, Fourth Military Medical University, Xi'an 710032, People's Republic of China.


Rifampin resistance in Mycobacterium tuberculosis could be determined within 2 h by using pyrosequencing-based approach. Pyrosequencing results of rifampin-resistant (n = 21) and rifampin-susceptible (n = 20) M. tuberculosis isolates were concordant with those based on drug susceptibility testing and conventional DNA sequencing. Results showed pyrosequencing-based approach is a rapid, sensitive, and efficient detection method of rifampin-resistant M. tuberculosis.

[Indexed for MEDLINE]

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