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Phys Rev Lett. 2005 Jan 14;94(1):018103. Epub 2005 Jan 6.

Robust formation of morphogen gradients.

Author information

1
Max-Planck-Institute for the Physics of Complex Systems, Nöthnitzer Strasse 38, 01187 Dresden, Germany.

Abstract

We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from the binding of ligands to receptors on the cell surface, incorporation into the cell, and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.

PMID:
15698137
DOI:
10.1103/PhysRevLett.94.018103
[Indexed for MEDLINE]
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