Send to

Choose Destination
Phys Rev Lett. 2005 Jan 14;94(1):018103. Epub 2005 Jan 6.

Robust formation of morphogen gradients.

Author information

Max-Planck-Institute for the Physics of Complex Systems, Nöthnitzer Strasse 38, 01187 Dresden, Germany.


We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from the binding of ligands to receptors on the cell surface, incorporation into the cell, and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for American Physical Society Icon for Spiral, Imperial College Digital Repository
Loading ...
Support Center