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Phys Rev Lett. 2004 Dec 31;93(26 Pt 1):268109. Epub 2004 Dec 23.

Cooperativity between cell contractility and adhesion.

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1
Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

Abstract

In living cells, the cytoskeleton connects to the extracellular environment through focal adhesions, multimolecular structures that can sense applied force. A model is presented that for the first time explains why the focal adhesions tend to high-curvature regions at the cell periphery. It is based on experimental evidence for positive feedback between adhesion formation and assembly of actomyosin bundles (stress fibers). The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient.

PMID:
15698031
DOI:
10.1103/PhysRevLett.93.268109
[Indexed for MEDLINE]
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