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J Clin Invest. 2005 Mar;115(3):711-7.

The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses.

Author information

1
Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA.

Abstract

Herpesvirus entry mediator (HVEM), a TNF receptor superfamily member, has been previously described as a T cell costimulatory receptor. Surprisingly, HVEM-/- T cells showed enhanced responses to in vitro concanavalin A (ConA) stimulation when compared with WT T cells. Consistent with these findings, HVEM-/- mice exhibited increased morbidity and mortality as compared with WT mice in a model of ConA-mediated T cell-dependent autoimmune hepatitis. HVEM-/- mice produced higher levels of multiple cytokines, which were dependent on the presence of CD4+ T cells. Furthermore, HVEM-/- mice were more susceptible to MOG peptide-induced experimental autoimmune encephalopathy, and they showed increased T cell proliferation and cytokine production in response to antigen-specific challenge. Taken together, our data revealed an unexpected regulatory role of HVEM in T cell-mediated immune responses and autoimmune diseases.

PMID:
15696194
PMCID:
PMC546456
DOI:
10.1172/JCI22982
[Indexed for MEDLINE]
Free PMC Article

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