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Nat Immunol. 2005 Mar;6(3):261-70. Epub 2005 Feb 6.

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse.

Author information

1
Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

Abstract

Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell receptor internalization but considerably affected T cell receptor-stimulated T cell activation by regulating multiple biochemical signaling pathways and the accumulation of F-actin at the immunological synapse. Moreover, Dyn2 interacted directly with the Rho family guanine nucleotide exchange factor Vav1, and this interaction was required for T cell activation. These data identify a functionally important interaction between Dyn2 and Vav1 that regulates actin reorganization and multiple signaling pathways in T lymphocytes.

PMID:
15696170
DOI:
10.1038/ni1168
[Indexed for MEDLINE]

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