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Curr Opin Microbiol. 2005 Feb;8(1):74-82.

Immune control of phagosomal bacteria by p47 GTPases.

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Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.


Sequestered from the action of complement, antibody and lytic peptides, phagosomal pathogens pose a unique problem for the innate immune system both in terms of detection and disposal. An immunologically induced 47-kDa (p47) GTPase family recruited to nascent phagosomes (PGs) has provided new insights into how vertebrates deal with facultative bacteria occupying a vacuolar niche. Research over the past 2 years in particular has identified several molecular determinants that underlie the membrane trafficking functions of LRG-47 and other p47 GTPases as part of a PG remodeling program. When coupled to signals issuing from pathogen-specific Toll-like receptors, the p47 proteins may constitute a novel sensory system enlisted by mammals, birds and fish to decode the language of immune recognition against this particular class of infectious agents.

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