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Curr Biol. 2005 Feb 8;15(3):R99-R102.

DNA repair: the importance of phosphorylating histone H2AX.

Author information

1
Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.

Abstract

How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.

PMID:
15694301
DOI:
10.1016/j.cub.2005.01.029
[Indexed for MEDLINE]
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