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J Craniomaxillofac Surg. 2005 Feb;33(1):50-4. Epub 2005 Jan 11.

Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites.

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1
Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, South Korea.

Abstract

AIM:

Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation.

MATERIAL AND METHODS:

The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period.

RESULTS:

The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type.

CONCLUSIONS:

This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.

PMID:
15694150
DOI:
10.1016/j.jcms.2004.05.011
[Indexed for MEDLINE]
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