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Fiziol Zh. 2004;50(5):73-9.

[Comparative evaluation of the effect of snake venoms on the system of hemocoagulation of animals].

[Article in Russian]

Abstract

The changes in some biochemical parameters of hemocoagulation in animals, intoxicated by venoms of three species of snakes have been investigated. The investigated venoms were: venoms of Armenian adder (Vipera raddei), Transcaucasian adder (V. lebetina) and red cobra (Naja pallidd). The results have shown, that the venoms of Transcaucasian adder and red cobra have coagulating effect. The influence of a venom of Armenian adder is expressed in general delay of process, however there is an amplification of fibrinolytic activity, that allows us to assume a development ofthe DIC-syndrom under influence of this venom. Considering results received by us regarding the influence of the venom of Armenian adder on the system of hemocoagulation, and also numerous data available in the literarature, we do not exclude an opportunity of the presence of disintegrins in this venom, which could present potential therapeutical interest. This allows us to assume a necessity of further investigation of this venom with attraction of the newest biochemical and biophysical methods and testing both whole venom, and its separate fractions.

PMID:
15693301
[Indexed for MEDLINE]

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