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Acad Radiol. 2005 Jan;12(1):51-7.

Proton magnetic resonance spectroscopy of brain tumors correlated with pathology.

Author information

1
Department of Radiology, School of Medicine, 3990 John R., Wayne State University, Detroit Medical Center, Detroit, MI 48201-2097, USA. amagalha@med.wayne.edu

Abstract

RATIONALE AND OBJECTIVES:

Evaluate proton magnetic resonance spectroscopy ((1)H-MRS) for assessing and grading brain tumors.

MATERIALS AND METHODS:

The research was done at Detroit Medical Center in a 1.5-T Siemens MR magnet using single-voxel or multivoxel MRS. This study consisted of 27 patients: 10 females and 17 males ages 22-83 years (average age 43.8). The data were recorded for three peaks-N-acetyl aspartate (NAA), choline (Cho), creatine (Cr)-which were used to calculate the ratios Cho/NAA and Cho/Cr.

RESULTS:

Abnormal spectra were seen in 25 patients and normal spectra in 2. In 16 patients with brain astrocytoma of various grades, the pathology grading was correlated with Cho/NAA and Cho/Cr. These values were 6.53 and 3.35 for nine patients with Grade 4 astrocytoma; 1.85 and 1.62 for three patients with Grade 3 astrocytoma; 2.21 and 1.50 for three patients with Grade 2 astrocytoma; and 1.45 and 1.49 for one patient with Grade 1 astrocytoma. The remaining nine patients with abnormal spectra were also correlated with pathology.

CONCLUSION:

MRS ratios can be used to differentiate malignant and nonmalignant lesions from normal brain tissue. In general, high-grade astrocytoma have higher Cho/NAA and Cho/Cr ratios compared with low-grade astrocytoma.

PMID:
15691725
DOI:
10.1016/j.acra.2004.10.057
[Indexed for MEDLINE]

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