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Trends Biochem Sci. 2005 Feb;30(2):66-9.

The LxxLL motif: a multifunctional binding sequence in transcriptional regulation.

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1
Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada.

Abstract

LxxLL motifs participate in many protein-protein interactions associated with different aspects of transcriptional regulation. These motifs are present in many transcription factors and cofactors, mediating interactions that can activate or repress transcription. Several recently reported 3D structures of protein-LxxLL motif complexes and an intriguing novel interaction implicated in leukaemia have further highlighted the diversity and regulatory importance of this seemingly simple motif.

PMID:
15691650
DOI:
10.1016/j.tibs.2004.12.001
[Indexed for MEDLINE]
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