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Transpl Int. 2005 Feb;18(2):131-9.

Protocol biopsies after kidney transplantation.

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1
Division of Nephrology and Dialysis, Department of Internal Medicine III, University of Vienna, Vienna, Austria. georg.boehmig@nephro.imed3.akh-wien.ac.at

Abstract

Numerous studies have investigated features of allograft injury in renal biopsies obtained in stable kidney transplants. Evaluation of protocol biopsies has revealed a considerably high prevalence of subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) already in early phases after transplantation. The meanwhile well-established association of SAR and CAN in protocol biopsy with long-term allograft failure and the finding of superior allograft outcome after treatment of SAR in a randomized prospective study may point to clinical relevance of this procedure. In this review, potential benefits and risks associated with kidney allograft biopsy in stable renal transplant recipients are discussed.

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