Send to

Choose Destination
Cell Transplant. 2004;13(7-8):823-31.

Maintenance of functional human cancellous bone and human hematopoiesis in NOD/SCID mice.

Author information

Department of Cytology and Histology, University of Liège, Liège, Belgium.


Attempts were made to establish models to study interactions between marrow stromal cells and hematopoietic cells in vivo. The approach was to create a NOD-SCID-hu murine model of long-term human hematopoiesis by implantation of a human adult bone fragment. Nine to 12 weeks posttransplantation, human CD45+ cells were detected in the blood and the spleen of some mice. The histology of the human transplant showed that human bone fragment was viable at 9 weeks. Moreover, vessels of human origin, as assessed by immunohistochemical detection of human beta2-microglobulin, were observed in the mouse tissue surrounding the transplanted human fragment.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Atypon Icon for ORBi (University of Liege)
Loading ...
Support Center