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Nat Rev Drug Discov. 2005 Jan;4(1):71-8.

Multicomponent therapeutics for networked systems.

Author information

1
CombinatoRx, Inc., 650 Albany Street, Boston, Massachusetts 02118, USA.

Abstract

Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.

PMID:
15688074
DOI:
10.1038/nrd1609
[Indexed for MEDLINE]

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