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Nat Rev Mol Cell Biol. 2005 Jan;6(1):69-78.

RNA polymerases I and III, growth control and cancer.

Author information

1
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, G12 8QQ, UK. rwhite@udcf.gla.ac.uk

Abstract

Transcription of rRNA and tRNA genes by RNA polymerases I and III is essential for sustained protein synthesis and is therefore a fundamental determinant of the capacity of a cell to grow. When cell growth is not required, this transcription is repressed by retinoblastoma protein, p53 and ARF. However, inactivation of these tumour suppressors in cancers deregulates RNA polymerases I and III, and oncoproteins such as Myc can stimulate these systems further. Such events might have a significant impact on the growth potential of tumours.

PMID:
15688068
DOI:
10.1038/nrm1551
[Indexed for MEDLINE]

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