Format

Send to

Choose Destination
Nat Rev Immunol. 2005 Feb;5(2):136-48.

The tetraspanin web modulates immune-signalling complexes.

Author information

1
Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, California 94305, USA. levy@cmgm.stanford.edu

Abstract

The tetraspanin web represents a new concept of molecular interactions in the immune system. Whereas most surface immune-modulating molecules involve receptor-ligand interactions, tetraspanins associate with partner proteins and facilitate their lateral positioning in the membrane. Moreover, the same tetraspanin molecule can associate with different proteins depending on the cell type. Most importantly, members of this family tend to associate with each other, together with their partners, in membrane microdomains that provide a scaffold for the transmission of external stimuli to intracellular-signalling components.

PMID:
15688041
DOI:
10.1038/nri1548
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center