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Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6.

Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Author information

1
Bristol Myers Squibb Co., Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08560, USA. soonghoon.kim@bms.com

Abstract

Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 K(i)=4.7 nM) that are potent inhibitors of MMP-13.

PMID:
15686921
DOI:
10.1016/j.bmcl.2004.12.016
[Indexed for MEDLINE]

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