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J Agric Food Chem. 2005 Feb 9;53(3):608-13.

Pachyelasides A-D, novel molluscicidal triterpene saponins from Pachyelasma tessmannii.

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1
Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA.

Abstract

This is the first report for secondary metabolites in an African medicinal plant, Pachyelasma tessmannii (Leguminosae). Four novel saponins, pachyelasides A-D, were isolated from the methanol extract of the root bark by using recycling HPLC. These compounds showed molluscicidal activity (LD(50) < or =8.0 mug/mL) against the South American snail, Biomphalaria glabratus. The structures were determined on the basis of extensive nuclear magnetic resonance spectroscopic and matrix-assisted laser desorption/ionization time-of-flight mass spectrometric studies.

PMID:
15686409
DOI:
10.1021/jf048570w
[Indexed for MEDLINE]

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